View Sickle Cell Anemia And Malaria Relationship US . At the same time, its epidemiology is a remarkable signature of the past and present world distribution of plasmodium falciparum malaria. In this brief review, in keeping with the theme of this journal, we focus on the close and complex. Royalty Free Sickle Cell Anemia Clip Art, Vector Images ... from media.istockphoto.com Symptoms of sickle cell anemia usually show up at a young age. In teaching, visualizing the complex relationship between two different diseases might be hard to do on paper; In early human societies, most children with sickle cell anemia likely died by age 5. Sickle cell anemia is a genetic disorder that can exist in the homozygous (2 genes for the trait) form or in the heterozygous form (1 sickle cell gene and one normal gene). At the same time, its epidemiology is a remarkable signature of the past and present